Polynucleotides for Neck Rejuvenation: A Promising Approach to Combat Skin Ageing
Introduction
Ageing affects all areas of the skin, but the neck is particularly prone to visible signs of ageing due to its thinner skin, frequent exposure to environmental stressors, and lower collagen density. Fine lines, sagging, and reduced elasticity are common concerns that many individuals seek to address. Traditional treatments, including laser therapy, radiofrequency, and dermal fillers, have shown effectiveness in rejuvenating the neck area. However, polynucleotide (PN) injections have emerged as an innovative and promising alternative for improving skin quality and reversing signs of ageing.
This article explores the role of polynucleotides in neck rejuvenation, with a particular focus on their effectiveness in enhancing skin elasticity, hydration, and firmness.
What Are Polynucleotides?
Polynucleotides (PNs) are biostimulatory molecules derived from highly purified fish DNA, typically sourced from salmon or trout. These molecules work by stimulating fibroblast activity, improving hydration, and promoting collagen and elastin synthesis. Their regenerative effects make them an excellent choice for treating skin ageing, particularly in delicate areas like the neck.
Unlike hyaluronic acid fillers, which primarily add volume, polynucleotides enhance the skin’s intrinsic regenerative processes, making them suitable for improving skin texture, elasticity, and hydration. Their ability to stimulate tissue repair also makes them a preferred option for individuals seeking a more natural-looking rejuvenation.
Mechanism of Action
Polynucleotides work through several key mechanisms:
Fibroblast Stimulation: PNs promote fibroblast proliferation, leading to increased collagen and elastin production, which helps to firm and tighten the skin.
Hydration Enhancement: PNs have strong water-binding properties, significantly improving skin hydration and preventing transepidermal water loss (TEWL).
Anti-Inflammatory Effects: PNs reduce oxidative stress and inflammation, supporting skin repair and minimising damage from environmental factors.
Tissue Regeneration: By activating tissue repair mechanisms, PNs enhance overall skin quality, improving texture and reducing the appearance of fine lines and wrinkles.
Clinical Evidence for Neck Rejuvenation
Several studies [1 ,2] have investigated the efficacy of polynucleotides in treating ageing neck skin, including the neck. A notable case study examined the effects of PN injections on a 59-year-old female patient from experiencing signs of neck ageing. The study compared two treatment regimens, each involving intradermal injections administered at different intervals:
Regimen A: Four treatments, each administered two weeks apart, on the left side of the neck.
Regimen B: Four treatments, each administered four weeks apart, on the right side of the neck.
The study assessed various skin parameters using advanced dermatological measuring devices, including the Cutometer Dual MPA 580, corneometer, mexameter, and evaporimeter. These tools provided objective data on skin elasticity, hydration, melanin levels, and transepidermal water loss.
Results and Findings of Polynucleotides for Neck in London
The study found that the patient tolerated PN injections well, with no persistent side effects reported. However, the effects of the two treatment regimens varied:
Skin Elasticity and Firmness: Regimen B, which involved injections spaced four weeks apart, demonstrated superior results in improving skin elasticity (R2 parameter). In contrast, Regimen A did not show significant changes in elasticity or firmness.
Skin Hydration: Both regimens contributed to increased hydration, but Regimen B was more effective, particularly in the mandibular region.
Pigmentation and Redness: Both regimens resulted in more stable melanin levels in the neck and mandibular areas. However, Regimen A was more effective in reducing skin redness.
Overall Skin Quality: Regimen B was more beneficial for overall skin improvement, suggesting that longer intervals between injections may allow for better tissue regeneration and collagen synthesis.
Polynucleotides for Neck in London
Discussion
These findings suggest that Polynucleotides for Neck in London can significantly enhance skin quality in the neck region [1]. However, the choice of treatment protocol plays a crucial role in determining outcomes. The study indicates that a spaced-out regimen (four-week intervals) provides more sustained benefits compared to more frequent treatments. This may be due to the need for adequate time for fibroblast stimulation and collagen remodelling.
Moreover, the study highlights that while PNs improve skin hydration, elasticity, and firmness, they produce mild effects compared to more invasive procedures. Thus, polynucleotides may be better suited for preventative treatments in mature patients rather than as a sole method for reversing advanced signs of ageing.
Clinical Implications
Polynucleotides offer an exciting alternative for neck rejuvenation, particularly for patients looking for a minimally invasive approach with natural results. Their ability to improve skin hydration, elasticity, and overall quality makes them an attractive option for individuals seeking preventative or mild anti-ageing treatments.
Practitioners should consider the following factors when recommending PN injections for the neck:
Patient Selection: Best suited for individuals with mild to moderate skin laxity and dehydration. [2]
Treatment Protocol: Longer intervals (four weeks) may provide better long-term results compared to more frequent sessions.
Combination Therapies: PNs can be combined with other skin-rejuvenating treatments such as microneedling, radiofrequency, or laser therapy for enhanced results.
Conclusion
Polynucleotide injections represent a promising addition to the field of non-surgical skin rejuvenation. While their effects are mild compared to more invasive procedures, they offer significant benefits in terms of hydration, skin quality, and elasticity, particularly for the delicate neck area. The results of clinical studies suggest that spacing injections four weeks apart may yield more sustained improvements than more frequent sessions.
As demand for natural and regenerative treatments continues to grow, polynucleotides are likely to become an integral part of anti-ageing protocols, offering patients a safe and effective option for maintaining youthful, healthy skin.
Future research should explore larger patient cohorts and long-term effects of polynucleotide therapy to establish optimal treatment protocols and maximise its benefits in aesthetic medicine.
When considering polynucleotide injections, choosing a reputable clinic and experienced practitioner can make all the difference in achieving successful results and reducing the risk of side effects.
Read more about polynucleotide Injections London, Side Effects and How to Manage Them here
Check with Skinoza team to see how well you are handling the polynucleotide treatment so you understand what can be done with it. This is all about helping you stay safe and at less of a risk of serious problems when using these.
Ask your trusted Skinoza clinic today for the procedure that suits you! Find Polynucleotide Treatment Near You:
1. Skinoza Orpington, Bromley near Chislehurst, Bickley, Beckenham, West Wickham, Sidcup and Swanley
2. Skinoza Greenwich near Canary Warf, Deptford, Surrey Quays and Kidbrooke Village
3. Skinoza Blackhorse Road, Walthamstow near Tottenham Hale and Seven Sisters
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Lis A., Kawałkiewicz W., Kubisz L. A comparison of the efficacy of reducing the signs of ageing in the neck skin after polynucleotides injections in regimens with different dosing intervals—A case study. J. Face Aesthet. 2023;6:28–45. doi: 10.20883/jofa.68. [DOI] [Google Scholar]
Minoretti P., Emanuele E. Clinically Actionable Topical Strategies for Addressing the Hallmarks of Skin Aging: A Primer for Aesthetic Medicine Practitioners. Cureus. 2024;16:e52548. doi: 10.7759/cureus.52548. [DOI] [PMC free article] [PubMed] [Google Scholar]
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